Reaction: The keratan chain can be capped by N-acetylneuraminic acid
- in pathway: Keratan sulfate biosynthesis
The human genes ST3GAL1-4 and 6 encode for sialyltransferase1-4 and 6 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa and Paulson, 1993, Basu et al. 1993, Okajima et al. 1999). They add a sialyl residue to the growing keratan chain, blocking any further chain elongation.
Reaction - small molecule participants:
CMP [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Reactome.org reaction link: R-HSA-2046285
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-2046285