Reaction: JNK phosphorylates BIM, BAD and other targets
- in pathway: NRAGE signals death through JNK
Once activated, JNK phosphorylates targets in cytoplasm, including BIM and BAD that promote the release of cytochrome c and activation of caspases 9, 6 and 3.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-205075
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-205075