Reaction: GTP-bound RAC contributes to JNK activation
- in pathway: NRAGE signals death through JNK
Ras-related C3 botulinum toxin substrate 1 (RAC1) activation was described as essential for p75NTR to induce MAPK8 (aka JNK) and apoptosis in cortical oligodendrocytes (Bazenet et al. 1998). The simultaneous activation of TRKA counteracts the apoptotic action of p75, by modulating the kinetics of p75-mediated RAC activation.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-205136
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-205136