Reaction: Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)
- in pathway: Metabolism of Angiotensinogen to Angiotensins
The binding of prorenin to the (pro)renin receptor activates the protease activity of prorenin, which can then hydrolyze angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Prorenin is inactive when not bound to the (pro)renin receptor. Aliskiren, a drug used clinically to treat hypertension, inhibits the cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2065357
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2065357