Reaction: Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
Delta2-THA-CoA is hydrated to 3-hydroxyacyl-CoA intermediate 1-(3-hydroxy-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA by HSD17B4/DBP (d-bifunctional protein) dimer.
Reaction - small molecule participants:
1-3-hydroxy-THA-CoA [peroxisomal matrix]
H2O [peroxisomal matrix]
delta2-THA-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-2066778
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Reaction input - small molecules:
water
(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA
Reaction output - small molecules:
(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA
Reactome.org link: R-HSA-2066778