Reaction: Conversion of DHA-CoA to docosahexaenoic acid (DHA)
- in pathway: alpha-linolenic acid (ALA) metabolism
DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).
Reaction - small molecule participants:
CoA-SH [peroxisomal matrix]
DHA [peroxisomal matrix]
H2O [peroxisomal matrix]
DHA-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-2066779
======
Reaction input - small molecules:
water
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
Reactome.org link: R-HSA-2066779