Reaction: Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
3-hydroxy tetracosahexaenoyl-CoA undergoes dehydrogenation to form 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA, catalysed by DBP. DBP is a bifunctional enzyme, involved in the hydration of a variety of trans-2,3-dehydroacyl-CoA's but also mediating dehydrogenation of a variety of 3-hydroxyacyl-CoA's (Jiang et al. 1997).
Reaction - small molecule participants:
1-3-oxo-THA-CoA [peroxisomal matrix]
1-3-hydroxy-THA-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-2066780
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Reaction input - small molecules:
(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA
Reaction output - small molecules:
(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA
Reactome.org link: R-HSA-2066780