Reaction: HS3ST1 sulfates GlcN at C3 in heparan sulfate
- in pathway: HS-GAG biosynthesis
Heparan sulfate 3-O-sulfotransferase1 (HS3ST1) transfers sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS. HS3ST1 is the rate limiting enzyme for synthesis of anticoagulant heparan sulfate. Unlike the other members of the HS3ST family, it is probably located in the Golgi lumen (Shworak et al. 1997).
Reaction - small molecule participants:
PAP [Golgi lumen]
PAPS [Golgi lumen]
Reactome.org reaction link: R-HSA-2076383
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-2076383