Reaction: HS2ST1 sulfates IdoA at C2 in heparan sulfate
- in pathway: HS-GAG biosynthesis
Human heparan sulfate L-iduronyl 2-O-sulfotransferase 1 (HS2ST1) mediates the transfer of sulfate from PAPS to the C2-position of iduronate (and glucuronate with lesser preference) (Smeds et al. 2010) residues in heparan sulfate chains (Rong et al. 2000).
Reaction - small molecule participants:
PAP [Golgi lumen]
PAPS [Golgi lumen]
Reactome.org reaction link: R-HSA-2076508
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-2076508