Reaction: Photolytic cleavage and thermal isomerization of 7-dehydroCHOL
- in pathway: Vitamin D (calciferol) metabolism
The skin's exposure to UV rays from sunlight induces the photolytic cleavage of 7-dehydrocholesterol to previtamin D3. This is followed by thermal isomerization to form vitamin D3 (VD3, cholecalciferol) (Holick et al. 1977).
Reaction - small molecule participants:
VD3 [endoplasmic reticulum membrane]
7-dehydroCHOL [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-209754
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Reaction input - small molecules:
cholesta-5,7-dien-3beta-ol
Reaction output - small molecules:
calciol
Reactome.org link: R-HSA-209754