Reaction: Decarboxylation of 5-hydroxytryptophan forms serotonin
- in pathway: Serotonin and melatonin biosynthesis
Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both dopa and 5-hydroxytryptophan to dopamine and serotonin, respectively. AADC functions as a homodimer, utilizing pyridoxal phosphate as a cofactor.
Reaction - small molecule participants:
CO2 [cytosol]
5HT [cytosol]
5HTP [cytosol]
Reactome.org reaction link: R-HSA-209859
======
Reaction input - small molecules:
5-hydroxy-L-tryptophan zwitterion
Reaction output - small molecules:
carbon dioxide
serotonin(1+)
Reactome.org link: R-HSA-209859