Reaction: Iodide is taken up by thyroid epithelial cells
- in pathway: Thyroxine biosynthesis
Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- symporter (sodium/iodide). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration 30-40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I-.
Reaction - small molecule participants:
I- [cytosol]
Na+ [cytosol]
I- [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-209910
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Reaction input - small molecules:
iodide
sodium(1+)
Reaction output - small molecules:
iodide
sodium(1+)
Reactome.org link: R-HSA-209910