Reaction: Monoiodinated tyrosine can be deiodinated

- in pathway: Thyroxine biosynthesis
The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).
Reaction - small molecule participants:
L-Tyr [extracellular region]
NADP+ [extracellular region]
I- [extracellular region]
NADPH [extracellular region]
MIT [extracellular region]
Reactome.org reaction link: R-HSA-209921

======

Reaction input - small molecules:
NADPH
ChEBI:16474
3-iodo-L-tyrosine
ChEBI:27847
Reaction output - small molecules:
L-tyrosine zwitterion
ChEBI:58315
NADP(+)
ChEBI:18009
iodide
ChEBI:16382
Reactome.org link: R-HSA-209921