Reaction: Diiodinated tyrosine can be deiodinated
- in pathway: Thyroxine biosynthesis
The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).
Reaction - small molecule participants:
L-Tyr [extracellular region]
NADP+ [extracellular region]
I- [extracellular region]
NADPH [extracellular region]
DIT [extracellular region]
Reactome.org reaction link: R-HSA-209960
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Reaction input - small molecules:
NADPH
3,5-diiodo-L-tyrosinate(1-)
Reaction output - small molecules:
L-tyrosine zwitterion
NADP(+)
iodide
Reactome.org link: R-HSA-209960