Reaction: Tyrosine is diiodinated
- in pathway: Thyroxine biosynthesis
Tyrosines can be iodinated in thyroglobulin to produce precursors for thyroid hormone synthesis.
Reaction - small molecule participants:
H2O [extracellular region]
DIT [extracellular region]
NADP+ [extracellular region]
H+ [extracellular region]
NADPH [extracellular region]
L-Tyr [extracellular region]
I- [extracellular region]
H2O2 [extracellular region]
Reactome.org reaction link: R-HSA-209973
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Reaction input - small molecules:
hydron
NADPH
L-tyrosine zwitterion
iodide
hydrogen peroxide
Reaction output - small molecules:
water
3,5-diiodo-L-tyrosinate(1-)
NADP(+)
Reactome.org link: R-HSA-209973