Reaction: Coumarin is 7-hydroxylated by CYP2A13
- in pathway: Xenobiotics
CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HCOU [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
COUM [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211881
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Reaction input - small molecules:
dioxygen
hydron
coumarin
NADPH
Reaction output - small molecules:
water
NADP(+)
umbelliferone
Reactome.org link: R-HSA-211881