Reaction: CYP3A7 can 6beta-hydroxylate testosterone
- in pathway: Xenobiotics
CYP3A7 is only expressed in fetal liver and not in adults. It has lower biotransformation capability than other members of the CYP3A family such as 3A4 or 3A5 but possesses a similar broad specificity. CYP3A7 plays a major role in fetal steroid hydroxylation, an example being the 6beta-hydroxylation of testosterone.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
6BHT [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
TES [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211882
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Reaction input - small molecules:
dioxygen
hydron
testosterone
NADPH
Reaction output - small molecules:
water
NADP(+)
6beta-hydroxytestosterone
Reactome.org link: R-HSA-211882