Reaction: CYP4F12 18-hydroxylates ARA
- in pathway: Fatty acids
Human CYP4F12 is involved in metabolism of endogenous compounds such as inflammatory mediators (arachidonic acid and prostaglandin H2) as well as xenobiotics like terfenadine (an antihistaminic drug) (Bylund et al. 2001). The omega-hydroxylation of arachidonic acid (ARA) is shown here to form 18-hydroxyarachidonic acid (18OH-ARA aka 18-HETE).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
18OH-ARA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
AA [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211904
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Reaction input - small molecules:
dioxygen
hydron
arachidonate
NADPH
Reaction output - small molecules:
water
NADP(+)
18-HETE(1-)
Reactome.org link: R-HSA-211904