Reaction: CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
- in pathway: Xenobiotics
Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HPTXL [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
PTXL [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211910
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Reaction input - small molecules:
dioxygen
hydron
paclitaxel
NADPH
Reaction output - small molecules:
water
NADP(+)
6-hydroxypaclitaxel
Reactome.org link: R-HSA-211910