Reaction: CYP4F8 19-hydroxylates PGH2
- in pathway: Eicosanoids
19-hydroxyprostaglandins E1 and E2 (19OH-PGE1 and 2) are major components of human seminal fluid. The initial step in their formation is the 19-hydroxylation of prostaglandin H1 and H2 (PGH1 and 2). CYP4F8 performs this initial conversion (Bylund et al. 1999, 2000). The example of PGH2 is used here.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
19OH-PGH2 [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211919
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Reaction input - small molecules:
dioxygen
hydron
prostaglandin H2
NADPH
Reaction output - small molecules:
water
NADP(+)
19-hydroxyprostaglandin H2
Reactome.org link: R-HSA-211919