Reaction: CYP2C19 5-hydroxylates omeprazole
- in pathway: Xenobiotics
Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HOMZ [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
Losec [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211929
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Reaction input - small molecules:
dioxygen
hydron
omeprazole
NADPH
Reaction output - small molecules:
water
NADP(+)
5'-hydroxyomeprazole
Reactome.org link: R-HSA-211929