Reaction: CYP24A1 24-hydroxylates CTL
- in pathway: Vitamins
Catabolic inactivation of the active, hormonal form of vitamin D3 (1,25-dihydroxyvitamin D3, calcitriol, CTL) is initially carried out by 24-hydroxylation, mediated by CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase). The product formed is eventually transformed to calcitroic acid (CTLA), the major water-soluble metabolite that can be excreted in bile.
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
CTLA [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CTL [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-211950
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Reaction input - small molecules:
dioxygen
hydron
calcitriol
NADPH
Reaction output - small molecules:
NADP(+)
(24S)-1alpha,24,25-trihydroxyvitamin D3
water
Reactome.org link: R-HSA-211950