Reaction: CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
- in pathway: Xenobiotics
Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HTOLB [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211988
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Reaction input - small molecules:
dioxygen
hydron
NADPH
Reaction output - small molecules:
water
NADP(+)
4-hydroxytolbutamide
Reactome.org link: R-HSA-211988