Reaction: Cyclophosphamide is 4-hydroxylated by CYP2B6
- in pathway: Xenobiotics
Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HCPM [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
CPM [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-211991
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Reaction input - small molecules:
dioxygen
hydron
cyclophosphamide hydrate
NADPH
Reaction output - small molecules:
water
NADP(+)
4-hydroxycyclophosphamide
Reactome.org link: R-HSA-211991