Reaction: CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
- in pathway: Xenobiotics
Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HPHT [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Phenytoin [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-212004
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Reaction input - small molecules:
dioxygen
hydron
NADPH
phenytoin
Reaction output - small molecules:
water
NADP(+)
4-hydroxyphenytoin
Reactome.org link: R-HSA-212004