Reaction: CYP2F1 dehydrogenates 3-methylindole
- in pathway: Xenobiotics
3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
3MEIN [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
MIND [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-212005
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Reaction input - small molecules:
dioxygen
hydron
skatole
NADPH
Reaction output - small molecules:
water
NADP(+)
3-methyleneindolenine
Reactome.org link: R-HSA-212005