Reaction: CYP4F3 20-hydroxylates LTB4
- in pathway: Eicosanoids
Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4). This deactivation can be carried out by CYP4F3 in addition to CYP4F2 (Kikuta et al. 1998).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
20OH-LTB4 [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
LTB4 [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-215526
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Reaction input - small molecules:
dioxygen
hydron
leukotriene B4
NADPH
Reaction output - small molecules:
water
NADP(+)
20-hydroxy-leukotriene B4
Reactome.org link: R-HSA-215526