Reaction: Interaction of integrin alphaDbeta2 with fibrin
- in pathway: Integrin cell surface interactions
Integrin alphaDbeta2 is a member of the beta2 family. It is expressed poorly on peripheral blood leukocytes but strongly on macrophages. alphaDbeta2 has the ability to interact with multiple ligands, including many ECM proteins. The interaction of beta2 integrins with ligands is mediated by their I-domains of the alpha subunits. The alphaD I-domain mediates the interaction with the ECM protein fibrinogen.
Reaction - small molecule participants:
Mg2+ [extracellular region]
Reactome.org reaction link: R-HSA-216069
======
Reaction input - small molecules:
magnesium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-216069