Reaction: HAS1,2,3 mediate the polymerization of HA
- in pathway: Hyaluronan biosynthesis and export
The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerization of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.
Reaction - small molecule participants:
GlcA-b1,3-GlcNAc [cytosol]
Reactome.org reaction link: R-HSA-2160851
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Reaction input - small molecules:
beta-D-GlcpA-(1->3)-D-GlcpNAc
Reaction output - small molecules:
Reactome.org link: R-HSA-2160851