Reaction: ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine
- in pathway: Purine salvage
Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.
Reaction - small molecule participants:
IMP [cytosol]
methylamine [cytosol]
N(6)-methyl-AMP(2-) [cytosol]
H2O [cytosol]
H+ [cytosol]
Reactome.org reaction link: R-HSA-2161187
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Reaction input - small molecules:
N(6)-methyl-AMP(2-)
water
hydron
Reaction output - small molecules:
IMP(2-)
methylammonium
Reactome.org link: R-HSA-2161187