Reaction: abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine
- in pathway: Abacavir metabolism
Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of abacavir monophosphate and water to form carbovir monophosphate and cyclopropylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).
Reaction - small molecule participants:
cyclopropylamine [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2161195
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Reaction input - small molecules:
water
Reaction output - small molecules:
cyclopropylamine
Reactome.org link: R-HSA-2161195