Reaction: PGH2 is reduced to PGF2a by FAM213B
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TXN) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011). This reaction has been inferred from an event in mice. An additional way of achieving this reaction involves the protein aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS.
Reaction - small molecule participants:
PGF2a [cytosol]
TXN-S2 [cytosol]
PGH2 [cytosol]
TXN-S2H2 [cytosol]
Reactome.org reaction link: R-HSA-2161612
======
Reaction input - small molecules:
prostaglandin H2
thioredoxin dithiol
Reaction output - small molecules:
prostaglandin F2alpha
thioredoxin disulfide
Reactome.org link: R-HSA-2161612