Reaction: PGH2 is degraded to 12S-HHT and MDA by TBXAS1
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Thromboxane synthase (TBXAS1) aka CYP5A1 facilitates rearrangement of the PGH2 endoperoxide bridge by a complementary mechanism to prostacyclin synthase, interacting with the C-9 oxygen to promote endoperoxide bond cleavage. The C-11 oxygen radical initiates intramolecular rearrangement, resulting in either the formation of thromboxane A2 (TXA2) or 12-hydroxyheptadecatrienoic acid (12S-HHT) and malonaldehyde (MDA) (Wang et al. 2001).
Reaction - small molecule participants:
12S-HHT [endoplasmic reticulum lumen]
MDA [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2161613
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Reaction input - small molecules:
prostaglandin H2
Reaction output - small molecules:
12S-HHTrE
malonaldehyde
Reactome.org link: R-HSA-2161613