Reaction: PGI2 is hydrolysed to 6k-PGF1a
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
The ring in prostaglandin I2 (PGI2) aka prostacyclin is highly labile and rapidly hydolyses to form the stable but biologically inactive 6-keto-prostaglandin F1alpha (6k-PGF1a) (Wada et al. 2004). PGI2 and 6k-PGF1a are often used interchangeably in the literature.
Reaction - small molecule participants:
6k-PGF1a [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
PGI2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2161619
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Reaction input - small molecules:
water
prostaglandin I2
Reaction output - small molecules:
6-oxoprostaglandin F1alpha
Reactome.org link: R-HSA-2161619