Reaction: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
15-Hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Cho et al. 2006). This reaction is inferred from rabbits (Bergholte & Okita 1986).
Reaction - small molecule participants:
H+ [cytosol]
NADH [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-2161662
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
hydron
NADH(2-)
Reactome.org link: R-HSA-2161662