Reaction: PGH2 is isomerised to PGD2 by HPGDS

- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, HPGDS with GSH promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Jowsey et al. 2001, Inoue et al. 2003).
Reaction - small molecule participants:
PGD2 [cytosol]
PGH2 [cytosol]
Reactome.org reaction link: R-HSA-2161701

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Reaction input - small molecules:
prostaglandin H2
ChEBI:15554
Reaction output - small molecules:
prostaglandin D2
ChEBI:15555
Reactome.org link: R-HSA-2161701