Reaction: TXB2 is converted to 11dh-TXB2 by TXDH
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Thromboxane B2 (TXB2) undergoes dehydrogenation at C-11 to form 11-dehydro-thromboxane B2 (11dh-TXB2). The enzyme responsible for catalysis has been termed 11-dehydroxythromboxane B2 dehydrogenase (TXDH) (Kumlin & Granström 1986, Catella et al. 1986, Westlund et al. 1994). The human TXDH isoform has not been cloned but 11dh-TXB2 has been detected in various experiments.
Reaction - small molecule participants:
H+ [endoplasmic reticulum lumen]
11dh-TXB2 [endoplasmic reticulum lumen]
NADH [endoplasmic reticulum lumen]
NAD+ [endoplasmic reticulum lumen]
TXB2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2161732
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Reaction input - small molecules:
NAD(1-)
thromboxane B2
Reaction output - small molecules:
hydron
11-dehydro-thromboxane B2
NADH(2-)
Reactome.org link: R-HSA-2161732