Reaction: EXA4 is converted to EXC4 by LTC4S
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
In addition to its role converting leukotriene A4 (LTA4) into leukotriene C4 (LTC4), the enzyme leukotriene C4 synthase (LTC4S) analogously converts eoxin A4 (EXA4), with reduced glutathione (GSH), to eoxin C4 (EXC4) (Feltenmark et al. 2008, Claesson et al. 2008).
Reaction - small molecule participants:
EXC4 [cytosol]
GSH [cytosol]
EXA4 [cytosol]
Reactome.org reaction link: R-HSA-2161768
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Reaction input - small molecules:
glutathionate(1-)
eoxin A4
Reaction output - small molecules:
eoxin C4
Reactome.org link: R-HSA-2161768