Reaction: 20cooh-LTB4 is converted to 18cooh-LTB4
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Once omega-oxidation has occurred, 20-carboxy leukotriene B4 (20cooh-LTB4) can be further metabolized by beta-oxidation at its omega end into 18-carboxy-LTB4 (18cooh-LTB4) (Berry et al. 2003, Wheelan et al. 1999). The actual human enzyme or enzymes involved have yet to be identified.
Reaction - small molecule participants:
18cooh-LTB4 [cytosol]
20cooh-LTB4 [cytosol]
Reactome.org reaction link: R-HSA-2161790
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Reaction input - small molecules:
20-hydroxy-20-oxoleukotriene B4
Reaction output - small molecules:
18-hydroxy-18-oxo-dinorleukotriene B4
Reactome.org link: R-HSA-2161790