Reaction: Arachidonic acid is converted to HXA3/B3 by ALOX12
- in pathway: Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Arachidonate 12-lipoxygenase, 12S-type (ALOX12) converts arachidonic acid to both hepoxilin A3 (HXA3) and B3 (HXB3). They both incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety with HXA3 having a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10 (Sutherland et al. 2001, Nigam et al. 2004).
Reaction - small molecule participants:
O2 [cytosol]
AA [cytosol]
Reactome.org reaction link: R-HSA-2161794
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Reaction input - small molecules:
dioxygen
arachidonate
Reaction output - small molecules:
Reactome.org link: R-HSA-2161794