Reaction: ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
- in pathway: Synthesis of Lipoxins (LX)
Arachidonate 5-lipoxygenase (ALOX5) converts 15R-hydro-eicosatetraenoic acid (15R-HETE) to the epi-lipoxins, 15epi-lipoxin A4 (15epi-LXA4) and 15epi-lipoxin B4 (15epi-LXB4) (Claria & Serhan 1995). These epi-lipoxins have altered configuration at the C-15 hydroxyl but similar biological potency.
Reaction - small molecule participants:
O2 [cytosol]
15R-HETE [cytosol]
Reactome.org reaction link: R-HSA-2161907
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Reaction input - small molecules:
dioxygen
15(R)-HETE
Reaction output - small molecules:
Reactome.org link: R-HSA-2161907