Reaction: ALOX5 oxidises 15S-HpETE to LXA4/B4
- in pathway: Synthesis of Lipoxins (LX)
Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.
Reaction - small molecule participants:
15S-HpETE [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-2161917
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Reaction input - small molecules:
15(S)-HPETE
dioxygen
Reaction output - small molecules:
Reactome.org link: R-HSA-2161917