Reaction: Arachidonic acid is converted to 12-oxoETE by ALOX12
- in pathway: Synthesis of 12-eicosatetraenoic acid derivatives
Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the formation of 12-oxo-eicosatetraenoic acid (12-oxoETE) from arachidonic acid. This conversion has been observed when normal human epidermis is exposed to arachidonic acid and with the purified recombinant enzyme in vitro (Anton & Vila 2000).
Reaction - small molecule participants:
12-oxoETE [cytosol]
AA [cytosol]
Reactome.org reaction link: R-HSA-2161948
======
Reaction input - small molecules:
arachidonate
Reaction output - small molecules:
12-oxo-ETE
Reactome.org link: R-HSA-2161948