Reaction: Arachidonic acid is oxidised to 12R-HpETE by ALOX12B
- in pathway: Synthesis of 12-eicosatetraenoic acid derivatives
The arachidonate 12-lipoxygenase, 12R-type (ALOX12B) oxidises arachidonic acid to 12R-hydroperoxy-eicosatetraenoic acid (12R-HpETE) (Boeglin et al. 1998).
Reaction - small molecule participants:
12R-HpETE [cytosol]
O2 [cytosol]
AA [cytosol]
Reactome.org reaction link: R-HSA-2161950
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Reaction input - small molecules:
dioxygen
arachidonate
Reaction output - small molecules:
12(R)-HPETE
Reactome.org link: R-HSA-2161950