Reaction: EET(1) is hydrolysed to DHET(1) by EPHX2
Epoxide hydrolase 2 (EPHX2) hydrolyses 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids ("EET(1)") to their corresponding dihydroxyeicosatrienoic acids ("DHET(1)") (Werner et al. 2002; Gomez et al. 2004). The majority of the EET biological activities are diminished by this hydrolysis.
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-2161961
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2161961