Reaction: LTA4 is hydrolysed to 6t-/6t,12epi-LTB4
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Non-enzymatic hydrolysis of the leukotriene A4 (LTA4) epoxide bond creates 6-trans leukotriene B4 (6t-LTB4) and 6-trans,12-epi leukotriene B4 (6t,12epi-LTB4) stereoisomers (Mansour & Agha 1999, Sirois et al. 1985).
Reaction - small molecule participants:
H2O [cytosol]
LTA4 [cytosol]
Reactome.org reaction link: R-HSA-2161962
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Reaction input - small molecules:
water
leukotriene A4
Reaction output - small molecules:
Reactome.org link: R-HSA-2161962