Reaction: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15
- in pathway: Synthesis of 12-eicosatetraenoic acid derivatives
Arachidonate 12-lipoxygenase, 12S-type (ALOX12) (Funk et al. 1990, Izumi et al. 1990) and arachidonate 15-lipoxygenase (ALOX15) (Kuhn et al. 1993, Sigal et al. 1990) convert arachidonic acid into 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE).
Reaction - small molecule participants:
12S-HpETE [cytosol]
O2 [cytosol]
AA [cytosol]
Reactome.org reaction link: R-HSA-2161964
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Reaction input - small molecules:
dioxygen
arachidonate
Reaction output - small molecules:
12(S)-HPETE
Reactome.org link: R-HSA-2161964