Reaction: LTA4 is converted to EXA4 by ALOX15
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Analogous to arachidonate 5-lipoxygenase (ALOX5) biosynthesis of leukotriene A4 (LTA4), arachidonate 15-lipoxygenase (ALOX15) can form an epoxide across C-14 and C-15 to form 14,15-LTA4 aka eoxin A4 (EXA4) (Feltenmark et al. 2008, Claesson et al. 2008).
Reaction - small molecule participants:
EXA4 [cytosol]
LTA4 [cytosol]
Reactome.org reaction link: R-HSA-2162019
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Reaction input - small molecules:
leukotriene A4
Reaction output - small molecules:
eoxin A4
Reactome.org link: R-HSA-2162019