Reaction: carbovir + IMP => carbovir monophosphate + inosine
- in pathway: Abacavir metabolism
NT5C2 catalyzes the reaction of carbovir and IMP to form carbovir monophosphate and inosine (Johnson and Fridland 1989; Miller et al. 1992). The enzyme was originally identified as a high-Km soluble 5'-nucleotidase most active on IMP and GMP (Spychala et al. 1988). Its active form is a tetramer (Wallden et al. 2007).
Reaction - small molecule participants:
Ino [cytosol]
IMP [cytosol]
Reactome.org reaction link: R-HSA-2162066
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Reaction input - small molecules:
IMP(2-)
Reaction output - small molecules:
inosine
Reactome.org link: R-HSA-2162066