Reaction: abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP
- in pathway: Abacavir metabolism
A member of the UDPGT (UDP-glucuronosyltransferase) enzyme family is thought to catalyze the reaction of abacavir and UDP-glucuronate to form UDP and abacavir-5'-glucuronate, one of the major forms in which abacavir is excreted from the body (McDowell et al. 1999; Ravitch and Moseley 2001). The specific UDPGT family enzyme family member or members that catalyze this reaction have not been identified.
Reaction - small molecule participants:
abacavir 5'-glucuronide [cytosol]
UDP [cytosol]
UDP-GlcA [cytosol]
Reactome.org reaction link: R-HSA-2162099
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
abacavir 5'-glucuronide
UDP(3-)
Reactome.org link: R-HSA-2162099